While the global HIV/AIDS response has dramatically improved service delivery, it has often done so without adequate focus on strengthening health systems. Meanwhile, policymakers and donors are rapidly embracing efforts to create resilient and sustainable systems that address multiple needs across national-level health platforms. The question is whether pivoting to a health system strengthening (HSS) approach can also be designed in a way that reinforces service delivery efforts and places patients at the centre of the health care system. This satellite will challenge global and national stakeholders to consider what patient-centred national-level HSS could look like, including clinical decision-making tools to address health disparities in women and children and improving the maternal and pediatric patient/caregiver experience. The satellite will also discuss real-life examples of how client based HSS better serves government officials, clinical providers and patients alike.