This 7th edition of the symposium will focus on providing skills to health professionals and community promoters on intersectionality, how it impacts transgender health and what interventions that address these aspects are available and have proven to be effective. In this symposium we will navigate the concept of intersectionality, highlighting the importance of addressing broader socio political issues when working with transgender people. We will examine the compounding effects of multiple stigmas on psychological health and will shed light on a critical but often overlooked aspect of transgender health, the intersectionality of sexualized substance use. Afterwards, we will discuss the challenges surrounding the accessibility and acceptability of Pre-Exposure and provide actionable insights into interventions aimed at addressing intersectionality and will provide actionable insights into interventions aimed at addressing intersectionality and improving HIV outcomes. Finally, panel