Brain health complications, including mild to moderate cognitive impairment and adverse mental health outcomes are a significant problem in persons with HIV on antiretroviral therapy (ART). While significant efforts have been dedicated to clinical studies and trials over the past two decades aimed at improving Brain Health outcomes (NeuroHIV) in persons with HIV, the results have been suboptimal. Researchers are now recognizing that, in addition to inflammation at the cellular level, various patient-level factors such as comorbid conditions, persistent CNS viral reservoirs, legacy effects, immune system dysfunction, social and structural factors, concomitant drug use and ART-related toxicity can influence CNS pathogenesis and outcomes. This meeting aims to bring together NeuroHIV experts from across the globe to formulate clinical guidelines and treatment strategies to improve Brain Health outcomes in persons with HIV.