Metabolism and inflammation during suppressive therapy
MODERATORS
Federico de América Perdomo Celis
Pontificia Universidad Javeriana, Colombia
Jeff Taylor
HIV + Aging Research Project, United States
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Despite viral suppression, chronic inflammation is observed during antiretroviral therapy. The causes are multiple, but inflammation is associated with the development of co-morbidities and complications in people living with HIV. In the past few years, the decisive role of cellular metabolism in the fate and activity of immune cells has been uncovered, as well as its impact on the outcome of infectious diseases. Emerging evidence suggests that immunometabolism has a key role in HIV-1 pathogenesis, including viral persistence, and cell metabolic products are key drivers of inflammation during infection. This symposium will summarize recent findings on drivers of chronic inflammation during treatment.
12:00
2 min
Introduction
HIV + Aging Research Project, United States
Pontificia Universidad Javeriana, Colombia
12:02
8 min
Metabolic reprogramming of Cd8 and NK cells
University College London, United Kingdom
12:10
8 min
Transcriptional inhibition under ART limits inflammation
University of North Carolina at Chapel Hill, United States
12:18
8 min
Metabolism, immunosenescence in suppressed HIV infection
The Wistar Institute, United States
12:26
8 min
Anti-ageing NMN enhances CD4 recovery by suppressing T cell hyperactivation during cART
The University of Hong Kong, Hong Kong, SAR of China
12:34
26 min
Q&A and conclusion
Pontificia Universidad Javeriana, Colombia
HIV + Aging Research Project, United States
University College London, United Kingdom
University of North Carolina at Chapel Hill, United States
The Wistar Institute, United States
The University of Hong Kong, Hong Kong, SAR of China