Impact of broadly neutralizing antibodies on HIV CNS reservoirs: Potential benefits, challenges and risks
CHAIR
Mario Stevenson, University of Miami, United States
Organizer
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Meeting goals
Broadly neutralizing antibodies (bNAbs) are being tested for prevention, treatment of HIV infections as well as attaining sustained virologic remission. Several clinical trials are being conducted/planned with bNAbs either alone or in combination with latency reactivating agents, immune activators or therapeutic vaccination. While extensive studies have been conducted with bNAbs in the periphery very limited data exists related to impacts in the CNS compartment. This satellite session will discuss new strategies to deliver broadly neutralizing antibodies through the blood brain barrier into the central nervous system. Data on impact of broadly neutralizing antibodies on CNS reservoirs will be presented. The potential CNS toxicity of bNAbs and compartmentalized development of resistance will also be discussed. A panel will be convened to identify research gaps and future priorities in this area.
07:30
5 min
Welcome and meeting goals
Division of AIDS Research, National Institute of Mental Health, United States
07:35
10 min
Human data on CNS penetration by VRC01 in studies from East Africa and Thailand
Walter Reed Army Institute of Research, United States
07:45
10 min
Gene edited B cells to co-express CNS-targeted broadly neutralizing antibodies
University of Southern California, United States
07:55
10 min
Vectored, ADCC-augmented broadly neutralizing antibodies for myeloid reservoir elimination
University of Miami, United States
08:05
10 min
Improved delivery of bNAbs using nanocapsules for targeting HIV CNS infection
University of California Los Angeles, United States
08:15
10 min
Bi-specific antibody-based eradication of HIV from the CNS reservoirs
University of Iowa, United States
08:25
10 min
Direct gene engineering of macrophages to express broadly neutralizing antibodies toward the eradication of brain reservoirs
University of Alabama at Birmingham, United States
08:35
10 min
Landscape of human immunodeficiency virus neutralization susceptibilities across tissue reservoirs including the brain
University of California, San Diego, United States
08:45
15 min
Q & A and future research priorities
University of Miami, United States
University of Southern California, United States
Walter Reed Army Institute of Research, United States
University of California, San Diego, United States
Division of AIDS Research, National Institute of Mental Health, United States
University of Alabama at Birmingham, United States
University of Iowa, United States
University of California Los Angeles, United States