The satellite focuses on the topic of biomedical HIV prevention choices that are now available: oral/long-acting PrEP and treatment as prevention (TasP). Experiences with TasP, and HIV stigma are being discussed jointly with data on user experience of oral and long-acting PrEP (e.g. SEARCH), as well as intention to use long-acting PrEP data (e.g. the European PROTECT survey w/ 20.000 participants). We will critically investigate tailored prevention potentials, unmet needs and access pathways and their impact on ending the HIV epidemic. As speakers, the following researchers covering the contexts in Europe (Kai Jonas, Johann Kolstee, Hanne Zimmermann, Haoyi Wang, The Netherlands), Southeast Asia (Natthakhet Yaemim, Thailand), Australasia (Martin Holt, Australia), Africa (Jane Kabami, Uganda), and the USA (Katie Biello) will contribute. In a panel, we are reflecting on the results with key populations represented by the following panelists Amanita Calderon-Cifuentes (Transgender Europe - TGEU), Juddy Otti (Africa Advocacy Foundation), Alex Schneider (Life4me+), Samira Hakim (Trans United Europe).