Despite harm reduction programmes being widely included in many national HIV plans across the region, a challenging legal environment, human rights violations, insufficient funding and military conflict are hindering an effective HIV and hepatitis (HCV) response. Moreover, the region is contending with a high prevalence of multidrug-resistant tuberculosis (TB) and of TB/HIV co-infection. The aim of the satellite is to help the audience gain a deeper understanding of the structural barriers impacting access to HIV, HCV and TB prevention and treatment services for people seeking care. It will showcase good practice models of community-led and integrated person-centred services, including those established for and by people who use drugs and people with lived experience of imprisonment. This session is addressed at clients, programme planners and implementers as well as policy makers.