Acute and protracted climatic events, hostile anti-LGBTQI environments, and political and civil unrest threaten to reverse gains in HIV prevention and treatment outcomes and disrupt even the most agile and adaptive HIV services. Synergistically, these multiple crises - or polycrises - create barriers to HIV and other lifesaving services that are in greater demand as HIV risk, trauma, violence, and other economic and social stressors are exacerbated. This session will explore the HIV response in the context of polycrises and highlight actions that actors are taking to promote preparedness and mitigate negative impacts. Speakers will share how HIV programmes have adapted to ensure continuity of HIV prevention, care and treatment in addition to other critical services to vulnerable groups; gaps that persist; and ways forward. The session will conclude with a call to action for donors, policy makers, implementers and communities.