Immune control of viral reservoirs
CO-CHAIRS
Marcus Altfeld, Leibniz-Institut für Virologie, Germany
Michaela Muller-Trutwin, Institut Pasteur, France
Organizer
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The complete elimination of infected cells (HIV cure) is challenging, even with aggressive strategies such as hematopoietic stem cell transplantation. On the other hand, the immune responses developed against HIV during natural infection present early alterations that ART cannot fully reverse, impairing the efficient immune control of infection upon ART interruption. Therefore, new targeted immunotherapies are among the priorities for HIV remission/cure approaches. Studies including extraordinary individuals who control HIV infection for decades in the absence of antiretroviral therapy (natural and post-treatment controllers) and in the natural hosts of simian immunodeficiency virus have provided unique insights into immune responses associated with durable viral control. These immune responses are thus optimal models to guide the development of efficient HIV immunotherapies. This satellite will discuss the study of such immune correlates of control and the development of novel immunotherapies for achieving HIV remission.
18:00
5 min
Welcome
ANRS Emerging infectious diseases (MIE), France
18:05
10 min
Exploring immune dysfunction in people living with HIV who initiated treatment in acute versus chronic phases of infection
Africa Health Research Institute (AHRI), South Africa
18:15
15 min
HIV-1 broadly neutralizing antibodies and their potential role in future cure strategies
University Hospital Cologne, Germany
18:30
10 min
MHC-E presentation of SIV-derived peptides mediated antigen-specific NK cell responses in SIV-infected rhesus macaques
Duke University, United States
18:40
15 min
Characterization of the HIV/SIV reservoir in viral control models - French cohort studies
University Hospital, Orleans University - Institut Cochin, Paris, France
18:55
10 min
Teaching an old dog a new trick: How to harness the immune system to control HIV
Emory University, United States
19:05
25 min
Q&A
Institut Pasteur, France
Leibniz-Institut für Virologie, Germany
Africa Health Research Institute (AHRI), South Africa
University Hospital Cologne, Germany
Duke University, United States
University Hospital, Orleans University - Institut Cochin, Paris, France
Emory University, United States